Lazy court-process clerk and stoner Dale Denton has only one reason to visit his equally lazy dealer Saul Silver: to purchase weed, specifically, a rare new strain called Pineapple Express. But when Dale becomes the only witness to a murder by a crooked cop and the city's most dangerous drug lord, he panics and dumps his roach of Pineapple Express at the scene. Dale now has another reason to visit Saul: to find out if the weed is so rare that it can be traced back to him--and it is. As Dale and Saul run for their lives, they quickly discover that they're not suffering from weed-fueled paranoia: incredibly, the bad guys really are hot on their trail and trying to figure out the fastest way to kill them both. All aboard the Pineapple Express. 菠萝快车：扬起屎尿屁的大旗。相当粗俗！。猥琐男们的卡通片。Love and Peace, man. Love and Peace.....。lsd和大麻。我要飞飞啊 之 菠萝快车。好好看。恶哈哈哈哈哈哈。从菠萝快车到不怎么红的James Franco。Gay味彌漫。 戴尔（塞斯•罗根 Seth Rogen 饰）有一份令自己和别人都生厌的工作——传票递送员，高中生女友安吉的帅气男同学们又时时令戴尔如坐针毡，于是抽大麻成了他最好的寄托甚至是信仰。戴尔定期在小混混索尔（詹姆斯•弗兰科 James Franco 饰）的家中购买大麻，索尔视其为朋友，推销给他最好的大麻“菠萝快车”，可戴尔只拿对方当做比自己更失败的落寞者。当晚戴尔偶然撞见当地大毒贩瑞德和一名女警联手杀人，慌不择路逃跑的戴尔将菠萝快车这种罕见大麻遗落在现场，担心被瑞德杀人灭口的戴尔和索尔只得选择逃亡，但他们谨慎又笨拙的隐匿方式只是将更多人卷入这场风波，而逃避性格的两人，在这次事件中渐渐学会正视自己的弱点……
